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. 2017 Dec 1;12(12):e0188473. doi: 10.1371/journal.pone.0188473

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© 2017 Lozano-Velasco et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) Pitx2 and Enpep gene expression in the adult left (LA) and right (RA) atrial chambers of spontaneous hypertensive rats (SHR) at 2 and 8 months, respectively, as compared to WHK controls. Observe that Pitx2 is significantly decreased in both atrial chambers in SHR hearts at 8 months, whereas Enpep display no significant differences at any of the analyzed stages. (B) AF GWAS-associated gene expression in the LA chamber of HTD hearts. Wnt8, Wnt11, Zfhx3 and Kcnn3 are significantly decreased in HTD hearts as compared to controls. (C) Ion channel encoding genes such as Kcnj2, Kcnj12, Atp2a2 (decreased), Scn5a and Pln (increased) display significant differential expression in HTD as compared to controls, while Scn1b, Ryr2, Casq2 and Camk2a display no significant differences. (D) Pitx2-regulated microRNAs display no significant differences, except for miR-26b and miR-106b which are significantly decreased, in HTD as compared to controls. In all cases, n = 6. *p<0.01, ** p<0.05, *** p<0.001.