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. 2017 Dec 1;12(12):e0188473. doi: 10.1371/journal.pone.0188473

Fig 5.

Fig 5

(A) Expression analyses of Pitx2c, Wnt8a, Wntt11 and Zfhx3 in gain- and loss-of-function experimental transfection of HL-1 atrial cardiomyocytes for Pitx2, Wnt8a, Wnt11 and Zfhx3, respectively. (B) Expression analyses of Cat and Sod2 in Pitx2 gain and loss-of-function experimental transfection of HL-1 atrial cardiomyocytes. Observe that only Pitx2c silencing (siPitx2c) significantly increases Cat expression. (C) Expression analyses of Cat and Sod2 in Wnt8a and Wnt11 gain of function transfections and Zfhx3 siRNA silencing (siZfhx3) of HL-1 atrial cardiomyocytes. Observe that Cat and Sod2 are significantly decreased in all cases, as compared to controls. Representative values of three pooled replicates on three independent biological transfections. *p<0.01, **p<0.05, ***p<0.001, ****p<0.0001.