Fig 6.

(A) Redox signaling gene expression analyses of H₂0₂ treated HL-1 atrial cardiomyocytes at 12 h and 24h. Observe that Cat, Sod2 and Prdx5 are significantly decreased at 12h and 24h after H₂0₂ administration, whereas Prdx2 is only decreased at 12h but not at 24h. (B) Gene expression analyses of Pitx2c, Wnt8a, Wnt11 and Zfhx3 after H₂0₂ administration. Observe that all of them are significantly decreased at 12h and 24h. (C) Gene expression analyses in Sod2 silenced HL-1 atrial cardiomyocytes. Note that Sod2 is decreased (siSod2), Pitx2c increases whereas Wnt8a, Wnt11 and Zfhx3 are significantly decreased. Representative values of three pooled replicates on three independent biological transfections. *p<0.01, **p<0.05, ***p<0.001, ****p<0.0001.