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. 2017 Dec 1;12(12):e0187631. doi: 10.1371/journal.pone.0187631

Fig 5. Sex and stress effects on microglial morphology and immune factor expression in dorsal hippocampus.

Fig 5

A. Total microglial density based on estimated volume. There were no effects of sex or stress on microglial density in stratum radiatum or oriens of CA3. B. Acute and chronic stress reduced the proportion of primed to surveillant microglia in stratum radiatum of CA3 in males only. Acute stress reduced the proportion of primed to surveillant microglia in stratum oriens of CA3 in females, whereas chronic stress decreased the proportion of primed to surveillant microglia in males. C. Acute stress induced CD40 expression in females only. Chronic stress increased CD40 transcript in males. D. Chronic stress heightened iNOS expression in males only. E. There were no effects of sex or stress on Arg1 transcript. F. Acute stress increased CX3CL1 mRNA in females, whereas chronic stress induced CX3CL1 in males. G. Acute stress induced CX3CR1 expression in males. H. Chronic stress increased CD200 transcript in males. I. There were no effects of sex or stress on CD200R expression. #p < .05, acute stress group compared to same-sex unstressed group. *p < .05, chronic stress group compared to same-sex unstressed group. Error bars indicate SEM. For graphs C-I, data are expressed relative to unstressed males.