Table 2. Sex-dependent stress effects on microglia in corticolimbic circuitry.
| Orbitofrontal Cortex | Basolateral Amygdala | Dorsal Hippocampus | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stress: | Acute | Chronic | Acute | Chronic | Acute | Chronic | ||||||
| Sex: | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ | ♂ | ♀ |
| Microglial density | - | - | - | ↓ | - | - | - | - | - | - | - | - |
| Microglial morphology | - | - | ↓ | - | ↓ | ↓ | ↓ | - | ↓ | - | ↓ | - |
| CD40 expression | - | - | - | - | ↑ | - | - | ↓ | - | ↑ | ↑ | - |
| iNOS expression | - | ↑ | ↑ | ↑ | - | - | - | ↑ | - | - | ↑ | - |
| Arg1 expression | - | - | - | ↑ | ↑ | ↓ | - | ↓ | - | - | - | - |
| CX3CL1 expression | - | - | ↑ | - | - | - | - | - | - | ↑ | ↑ | - |
| CX3CR1 expression | ↑ | - | - | ↑ | ↑ | - | - | - | ↓ | - | - | - |
| CD200 expression | - | ↑ | - | ↑ | - | - | - | - | - | - | ↑ | - |
| CD200R expression | - | - | ↑ | - | ↑ | - | ↑ | - | - | - | - | - |
Note: ↑ (green) indicates increased microglial density, morphological activation, or gene expression compared to same-sex unstressed group; ↓ (red) indicates decreased microglial density, morphological activation, or gene expression compared to same-sex unstressed group.