Table 1. Default parameter values.

protein concentrations [nM]	dissociation constants [nM]	dissociation rate constants [s−1]	scale factors (dimensionless)
Cul1T = 300 (a)	Ksr = 2.25 ⋅ 10−4 (c)	ksr = 9 ⋅ 10−7 (c)	η = Kca/Ksr = 0.077
SRT (b) = 660 (a)	$K_{sr}^{\prime }=650$ (c)	$k_{sr}^{\prime }=1.3$ (c)	α = kca/ksr = 11.11
Cand1T = 390 (a)	Kca = 1.73 ⋅ 10−5 (d)	$k_{ca}^{\prime }=1·{10}^{-5}$ (c)	$\beta =k_{ca}^{\prime }/k_{sr}^{\prime }=0.031$
	$K_{ca}^{\prime }=50$ (c)	$k_{ca}^{\prime }=0.04$ (e)

^(a) Ref. [9],

^(b) SR_T = SR1_T + SR2_T,

^(c) Ref. [10],

^(d) computed from Eq (1),

^(e) cf. Materials and Methods.