Three program approaches for implementing integrated zoonotic disease detection, prevention, and control programs. A) Comprehensive (umbrella) approach, designed to accelerate collaboration and impact. B) Phased (stepwise) approach in which each step building on prior developed program areas and capacities. C) Pathogen discovery approach, based on the necessity of early intersectoral collaboration to generate knowledge in the context of discovering an emerging zoonotic pathogen, which can subsequently take an umbrella or stepwise approach for program implementation.