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Cumulative incidence during the EDIC study of the first occurrence of any CVD event with INT (P = 0.23, log-rank test) (A) or CONV (P = 0.81, log-rank test) (B) for type 1 diabetes and of nonfatal MI, stroke, or death from CVD (MACE) with INT (P = 0.93, log-rank test) (C) or CONV (P = 0.52, log-rank test) (D) for type 1 diabetes therapy. Excessive = fourth quartile of weight gain (red lines); minimal = first through third quartiles of weight gain combined (blue lines).
