Table 2.
Unadjusted | Partially adjusted | Fully adjusted | |
---|---|---|---|
Any CVD event | 1.99 (1.12–3.53) | 1.62 (0.90–2.92) | 1.57 (0.86–2.86) |
MACE | 1.04 (0.48–2.22) | 0.91 (0.41–2.00) | 0.79 (0.35–1.76) |
Data are hazard ratios (95% CI). Cox proportional hazard regression models were unadjusted; partially adjusted for age at DCCT closeout, sex, and the following time-dependent covariates: smoking, sustained AER ≥30 mg/24 h or end-stage renal disease, estimate glomerular filtration rate <15 mL/min/1.73 m2 or end-stage renal disease, aspirin use, hormone replacement therapy use, and DCCT/EDIC time-weighted mean HbA1c; and fully adjusted to include also the following time-dependent covariates: systolic and diastolic blood pressures, antihypertensive medication use, total cholesterol, triglycerides, and lipid-lowering medication use. MACE include nonfatal myocardial infarction or stroke, or CVD-related death.