Table 2.

Association in the DCCT INT group between excessive (quartile 4) and minimal (quartiles 1–3 combined) weight gain during DCCT and subsequent cardiovascular events after 14 years of EDIC follow-up

	Unadjusted	Partially adjusted	Fully adjusted
Any CVD event	1.99 (1.12–3.53)	1.62 (0.90–2.92)	1.57 (0.86–2.86)
MACE	1.04 (0.48–2.22)	0.91 (0.41–2.00)	0.79 (0.35–1.76)

Data are hazard ratios (95% CI). Cox proportional hazard regression models were unadjusted; partially adjusted for age at DCCT closeout, sex, and the following time-dependent covariates: smoking, sustained AER ≥30 mg/24 h or end-stage renal disease, estimate glomerular filtration rate <15 mL/min/1.73 m² or end-stage renal disease, aspirin use, hormone replacement therapy use, and DCCT/EDIC time-weighted mean HbA_1c; and fully adjusted to include also the following time-dependent covariates: systolic and diastolic blood pressures, antihypertensive medication use, total cholesterol, triglycerides, and lipid-lowering medication use. MACE include nonfatal myocardial infarction or stroke, or CVD-related death.