. 2017 Oct 23;158(12):4129–4138. doi: 10.1210/en.2017-00637

Table 1.

Comparative Physiology of the Adrenal Cortex: From Mice to Humans

Function	Humans	Cows, Pigs, Dogs, and Sheep	Mice and Rats
Key gene for mineralocorticoid biosynthesis in zG	CYP11B2	CYP11B^a	Cyp11b2
Principal mineralocorticoid	Aldosterone	Aldosterone	Aldosterone
Key gene or genes for glucocorticoid biosynthesis in zF	CYP11B1	CYP11B^a	Cyp11b1
Key gene or genes for glucocorticoid biosynthesis in zF	CYP17	CYP17	Cyp11b1
Principal glucocorticoid	Cortisol	Cortisol	Corticosterone
Adrenal androgen synthesis	Present	Present	Absent

^{^a}

Expressed in zG and zF.