Table 1.

Main differences between cKpn and hvKpn strains.

Feature	cKpn	hvKpn
Infections	Urinary tract infections, pneumonia, bloodstream infections, wound surgical infections and meningitis, mainly in alcoholics, elderly adults, patients undergoing invasive procedures or have significant comorbidities and immunocompromised patients. These infections are mainly nosocomial-acquired	Liver, lungs, kidney, bones, prostate abscesses and necrotizing fasciitis have been already described. Invasive infections to eye and central nervous system from this primaries sites of infection even in healthy adults. These infections are usually acquired in community.
Antimicrobial susceptibility	Multidrug-resistant strains represent the main threat in this variants of K. pneumoniae. Strains harboring extended-spectrum β-lactamases (ESBLs) and carbapenemases genes are a clear example.	The first cases of these variants showed a susceptibility phenotype to several classes of antimicrobials. Worryingly, hypervirulent and multi-drug resistant strains have now been described. hvKpn strains harboring ESBLs, carbapenemases or mcr-1 genes have been described.
Virulence-associated genes	Mainly enterobactin, aerobactin, yersiniabactin and salmochelin.	rmpA, rmpA2, aerobactin, yersiniabactin, pld1, KpnO porin and higher content of capsular sialic acid