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. 2017 Jan 23;8(7):1229–1244. doi: 10.1080/21505594.2017.1284735

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© 2017 Taylor & Francis

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Figure 8. — CVB4 footprints on CAR during persistent infection in Panc-1 cells. Mutations with a frequency ≥ 20% obtained by deep sequencing of 2 CVB4 independent acute infections and 2 independent persistent infections in Panc-1 cells, were integrated in the sequence of the CVB4E2 published strain (Accession number: AF311939.1). Translated amino acid sequences were obtained using blastx (NCBI). VP1(a) and VP2(b) sequences were aligned along with sequences corresponding to CVB3/28 and CVB3/Nancy strains, using Uniprot software. Footprints of the virus on CAR are shown in blue boxes.