Figure 5.
Clearance of M. smegmatis (MSM) depends on IFN-I signaling. C57BL/6 mice and IFNAR−/− mice (n = 5–6/group) were injected with PBS, MAP and MSM. (A and B) body weight was monitored. ***p<0.001 by Two way ANOVA with Bonferroni post test, means ± SEM. (C) spleen weights at 21 dpi. *p<0.05, **p<0.01, ***p<0.001 by one-way ANOVA with Tukey post test, means ± SEM. (D) Numbers of CFU in liver, (E) spleen and (F) mesentery were determined by plating 21 dpi. Data are representative of 2 independent experiments, *p<0.05, ** p<0.01, ns (non-significant), by Mann-Whitney U test, means ± SEM.