Table 4.
Clinical characteristics of patients with T6SS+ A. baumannii bacteremia.a
| Total(n = 162) | T6SS+(n = 45, 28.4%) | T6SS–(n = 117, 71.3%) | P-value | |
|---|---|---|---|---|
| Age, years | 62.2 ± 14.7 | 61.6 ± 12.5 | 62.5 ± 15.5 | 0.710 |
| Male gender | 94 (58.0) | 27 (60.0) | 67 (57.3) | 0.859 |
| Underlying disease | ||||
| Immunocompromised status | 109 (67.3) | 35 (77.8) | 74 (63.2) | 0.093 |
| Solid tumor | 47 (29.0) | 11 (24.1) | 36 (30.8) | 0.449 |
| Hematologic malignancy | 32 (19.8) | 10 (22.2) | 22 (18.8) | 0.662 |
| HSCT | 10 (6.2) | 6 (13.3) | 4 (3.4) | 0.029c |
| Immunosuppressive agents | 75 (46.3) | 28 (62.2) | 47 (40.2) | 0.014 |
| Neutropenia | 32 (19.8) | 8 (17.8) | 24 (20.5) | 0.827 |
| Chronic renal disease | 52 (32.1) | 14 (31.1) | 38 (32.5) | 1.000 |
| Hemodialysis | 17 (10.5) | 8 (17.8) | 9 (7.7) | 0.084c |
| Congestive heart failure | 23 (14.2) | 4 (8.9) | 19 (16.2) | 0.317 |
| Liver cirrhosis | 18 (11.1) | 5 (11.1) | 13 (11.1) | 1.000 |
| Diabetes mellitus | 52 (32.1) | 14 (31.1) | 38 (32.5) | 1.000 |
| Comorbid conditions | ||||
| Septic shock | 80 (49.4) | 21 (46.7) | 59 (50.4) | 0.727 |
| Acute kidney injury | 68 (42.0) | 16 (35.6) | 52 (44.4) | 0.375 |
| Mechanical ventilation care b | 81 (50.0) | 15 (33.3) | 53 (45.3) | 0.214 |
| Surgery within 30 d | 45 (27.8) | 12 (26.7) | 33 (28.2) | 1.000 |
| Pitt bacteremia score | 3.3 ± 2.9 | 3.1 ± 2.6 | 3.4 ± 3.0 | 0.515 |
| Charlson WIC | 3.2 ± 2.6 | 3.4 ± 2.9 | 3.1 ± 2.4 | 0.525 |
| Site of infection | ||||
| Pneumonia | 59 (36.4) | 12 (26.7) | 47 (40.2) | 0.145 |
| CRBSI | 41 (25.3) | 20 (44.4) | 21 (17.9) | 0.001 |
| Intra-abdominal infection | 34 (21.0) | 4 (8.9) | 30 (25.6) | 0.303 |
| Primary bacteremia | 17 (10.5) | 4 (8.9) | 13 (11.1) | 0.782c |
| Skin and soft tissue infection | 8 (4.9) | 4 (8.9) | 4 (3.4) | 0.219c |
| Urinary tract infection | 3 (1.9) | 1 (2.2) | 2 (1.7) | 1.000 |
| Polymicrobial bacteremia | 32 (19.8) | 9 (20.0) | 23 (19.7) | 1.000 |
| Bacteremic episodes in ICU | 99 (61.1) | 29 (64.4) | 70 (59.8) | 0.719 |
| Hospital-acquired infection | 149 (92.0) | 44 (97.8) | 105 (89.7) | 0.114c |
| Appropriate antibiotics ≤ 48 h | 57 (35.2) | 16 (35.6) | 41 (35.0) | 1.000 |
| Antibiotic resistance | ||||
| MDR | 144 (88.9) | 41 (91.1) | 103 (88.0) | 0.781 |
| CR | 137 (84.6) | 40 (88.9) | 97 (82.9) | 0.468 |
| XDR | 132 (81.5) | 40 (88.9) | 92 (78.6) | 0.176 |
| 30-day mortality | 94 (58.0) | 25 (55.6) | 69 (59.0) | 0.725 |
Notes.
a
Data are expressed as no. (%) of patients, unless otherwise indicated. Continuous variables expressed as mean and standard deviation. Bold indicates P < 0.05. HSCT, haematopoietic stem cell transplantation; WIC, weighted index of comorbidity; CRBSI, catheter-related bloodstream infection; ICU, intensive care unit; MDR, multidrug-resistant; CR, carbapenem-resistant; XDR, extensively drug-resistant;
b
Mechanical ventilation care before bacteremia onset;
c
Fisher's exact test