Figure 7.

Complement independent protection by A1102. (A) Protective efficacy of A1102 was compared in cobra venom factor-treated (complement depleted) vs mock-treated mice. Groups of 5 mice each received 1 U of CVF (or buffer control) i.p. 30 h before challenge, followed by the indicated doses of A1102 (i.p., 6 h later). Challenge by Kp151 was performed intravenously 24 h after passive immunization with simultaneous GalN sensitization. (B) Efficacy of A1102 compared with its N297Q (aglycosylated) version. Groups of 5 mice were immunized with the indicated amount of antibodies. Challenge by Kp151 was performed intravenously 24 h after passive immunization with mAbs at the time of GalN sensitization. Lethality was monitored daily for 10 d.