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Synthetic transcription factors built on the dSpCas9:gRNA system. The fusion of an activation domain such as VP64 (A) or a repression domain like KRAB (B) to dSpCas9 confers to the dSpCas9:gRNA system the ability to regulate transcription initiation from eukaryotic promoters. A line ending with an empty circle is used here (an in the next Figures) to depict the recruitment of RNA polymerase II molecules (RNAP) to the DNA.**
