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. 2017 Oct 30;69(12):2303–2313. doi: 10.1002/art.40227

Table 3.

Association of antibodies with risk factors for RAa

Risk factor Smoking history HLA−DRB1 SE positive PD
Never smoked Former smoker Current smoker
CCP‐2+ (n = 240) 37 43 21 81 37
CCP‐2− (n = 44) 45 48 7 49 23
P 0.076 <0.001b 0.085b
cFIBβ+ (n = 190) 35 39 25 79 41
cFIBβ− (n = 97) 42 51 7 69 24
P 0.001 0.061 0.005
cVIM+ (n = 92) 39 41 20 92 36
cVIM− (n = 195) 37 44 19 68 34
P 0.902 <0.001 0.802
CEP‐1+ (n = 95) 27 48 24 88 41
CEP‐1− (n = 192) 43 41 17 69 32
P 0.034 0.001 0.12
cTNC5+ (n = 145) 35 43 22 80 37
cTNC5− (n = 142) 40 44 16 71 33
P 0.412 0.085 0.539
cCK13‐1+ (n = 69) 42 35 23 72 38
cCK13‐1− (n = 218) 36 46 18 77 34
P 0.256 0.451 0.57
a

Values are the percent of patients. Except where indicated otherwise, chi‐square tests were used to compare frequency distributions of categorical variables. RA = rheumatoid arthritis; SE = shared epitope; PD = periodontitis; CCP‐2 = cyclic citrullinated peptide 2; cFIBβ = citrullinated fibrinogen β; cVIM = citrullinated vimentin; CEP‐1 = citrullinated α‐enolase peptide 1; cTNC5 = citrullinated tenascin‐C; cCK13‐1 = citrullinated cytokeratin 13–derived peptide 1.

b

By Fisher's exact test.