TABLE 1.

Pathways not contributing to the enhancing effect of IL-22 on TNF-α-induced CXCL8 secretion.

Signaling Pathway	Inhibitor	Effect of Inhibitor on IL-22-Induced Enhancement*
JAK2/STAT3	WP1066	None
STAT1	Fludarabine	None
Tyk2	Bayer-18	None
PI3K	Wortmanin	None
Akt/PKB	Triciribine	None
JNK	SP600125	None
ERK1/2	PD98059	None

^*Cultures of HT-29 cells were cultured with the appropriate concentrations of the inhibitors, with or without IL-22 and/or TNF-α as in Fig. 3.