Table 1. CF and cardiodynamics in isolated hearts.
| Parameters | Baseline | Reperfusion (30 minutes) | Reperfusion (120 minutes) | |
|---|---|---|---|---|
| CF (mL/min/g) | ||||
| CON | 12.7±3.5 | 7.8±4.8 | 7.5±5.0 | |
| IPOC | 11.2±2.8 | 8.5±2.7 | 5.9±2.7 | |
| AMD+IPOC | 11.3±1.8 | 6.9±2.9 | 4.3±3.2 | |
| AMD | 13.0±2.6 | 8.2±6.8 | 5.6±5.1 | |
| HR (beats/min) | ||||
| CON | 272.4±32.5 | 235.2±43.1 | 202.4±74.5 | |
| IPOC | 257.6±16.7 | 228.7±29.7 | 176.0±54.4 | |
| AMD+IPOC | 258.7±43.1 | 186.4±67.7 | 158.8±62.5 | |
| AMD | 284.5±49.3 | 189.3±58.0 | 177.0±57.4 | |
| LVDP (mmHg) | ||||
| CON | 124.8±20.6 | 77.8±24.4 | 47.1±19.2 | |
| IPOC | 122.6±14.3 | 88.2±22.9 | 53.1±25.7 | |
| AMD+IPOC | 124.7±25.0 | 71.3±33.8 | 46.0±24.4 | |
| AMD | 127.4±27.5 | 53.3±19.8 | 46.9±16.9 | |
| RPP (mmHg·beats/min·103) | ||||
| CON | 34.0±7.0 | 19.0±8.8 | 10.4±7.4 | |
| IPOC | 31.7±5.1 | 20.4±6.5 | 10.4±6.1 | |
| AMD+IPOC | 32.1±7.5 | 14.5±9.9 | 7.4±5.6 | |
| AMD | 36.3±10.8 | 9.3±5.3 | 8.9±5.2 | |
| +dP/dtmax (mmHg/sec·103) | ||||
| CON | 2.6±1.0 | 1.5±0.5 | 0.9±0.3 | |
| IPOC | 2.6±0.3 | 1.7±0.4 | 1.1±0.5 | |
| AMD+IPOC | 2.4±0.7 | 1.3±0.6 | 0.8±0.3 | |
| AMD | 2.5±0.4 | 1.0±0.3 | 0.7±0.4 | |
Data expressed as mean±standard deviation.
AMD = AMD3100 treatment in CON (n=9); AMD+IPOC = CXCR4 antagonist AMD3100 treatment in IPOC (n=11); CF = coronary flow; CON = untreated control hearts (n=12); CXCR4 = chemokine receptor type 4; HR = heart rate; IPOC = ischemic postconditioning (n=8); LVDP = left ventricular developed pressure; RPP = rate-pressure product; +dP/dtmax = maximum first derivative of left ventricular pressure.