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. 2017 Nov 27;8:1664. doi: 10.3389/fimmu.2017.01664

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Copyright © 2017 Bietz, Zhu, Xue and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tools for modulating cholesterol metabolism of T cells. Summary of demonstrated tools for the modulation of T cell activity by targeting cholesterol metabolism in disease contexts. Tumor-infiltrating T cells are characteristic of hypoactivity, whereas auto-reactive T cells are of hyperactivity. Therefore, different strategies should be applied to modulate cholesterol metabolism in different disease contexts. Specific reagents as well as the observed effects on the cell are summarized. Avasimibe: inhibitor of acyl-coenzyme A: cholesterol acyltransferase; GW3865: agonist of liver X receptor; methyl-β-cyclodextrin: strong cholesterol binder that can deplete membrane cholesterol; atorvastatin: inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.