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. 2017 Nov 27;8:868. doi: 10.3389/fphar.2017.00868

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Copyright © 2017 Sharath Babu, Anand, Ilaiyaraja, Khanum and Gopalan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GRAPHICAL ABSTRACT — Schematic model of the Keap1/Nrf2 signaling pathway. Pelargonidin chloride dissociates Nrf2 from Keap1 resulting in translocation of Nrf2 into the nucleus, where it binds to ARE and activates cytoprotective genes.