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. 2017 Dec 1;7:16742. doi: 10.1038/s41598-017-17026-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analysis between striatal volumes and resting-state brain regional functional connectivity in the N171–82Q HD (n = 13 mice) and their littermate control mice (n = 7 mice). (A–D) Striatal atrophy and altered resting-state functional connectivity was detected in HD mice compared those in age-match control mice. p < 0.05 compared to the value in the control group by standard Student’s t-test. (E) Positive correlation between striatal volume and bilateral striatum connectivity in all mice, n = 20. (F) Positive correlation between striatal volume and intra-striatal resting-state functional connectivity in all mice, n = 20. (G) Negative correlation between striatum volume and connectivity between striatum and retrosplenial cortex (RC) in all mice, n = 20. (H) Correlation between striatal volume and striatum-RC connectivity in HD mice only. n = 13. The correlation was analyzed by Pearsonian correlation modeling.