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. 2017 Dec 1;7:16784. doi: 10.1038/s41598-017-17021-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Lck expression affects CLL cell sensitivity to fludarabine but not dexamethasone. CLL cell sensitivity to (a) dexamethasone (presented as % induction of cell death) or (b) fludarabine (presented as concentration (nM) where 90% of cells have undergone apoptosis, LC₉₀) was compared between CLL cells from cases in cohort 1 with high (>129 pg/10 μg total cellular protein) or low (<129 pg/10 μg total cellular protein) levels of Lck expression using data that corresponded to cases also used in Melarangi et al.³². Statistical significance for both parts of this figure was performed using a Mann-Whitney U-test.