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. 2017 Dec 1;8:1896. doi: 10.1038/s41467-017-01917-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — The Nlrp3 ^R258W x Rag1 ^−/− mice develop spontaneous colitis. a–e Characterization of the spontaneous colitis in Nlrp3 ^R258W x Rag1 ^−/− mice (n = 5) together with Rag1 ^−/− (n = 5) and Nlrp3 ^R258W (n = 4) mice as control, the morphology (a), colon length (b), feces score (c), and histological examination (d), scale bar is 200 μm, and histological score (e) of Rag1 ^−/−, Nlrp3 ^R258W, and Nlrp3 ^R258W × Rag1 ^−/− mice were monitored. f, g The indicated inflammatory cytokine/chemokine expression (f) and secretion (g) from the colon tissue of indicated mice were determined through Q-PCR and ELISA, respectively. Data are shown as the means ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA with Dunnett’s post-hoc test)