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. 2017 Dec 1;8:1892. doi: 10.1038/s41467-017-00320-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Manhattan plot representation of the step-wise conditional logistic regression of risk of a nodular sclerosis Hodgkin lymphoma and b mixed cellularity Hodgkin lymphoma within the human leukocyte antigen (HLA) region. (a1) Unconditioned test of the HLA region. (a2) Results of the HLA region after conditioning on rs9269081. (a3) Results of the HLA region after conditioning on rs9269081 and HLA-DPB1*03:01. (b1) Unconditioned test of the HLA region. (b2) Results of the HLA region after conditioning on rs1633096. (b3) Results of the HLA region after conditioning on rs1633096 and rs13196329. Physical positions are based on NCBI build 36 of the human genome. The −log₁₀ of the combined logistic regression test P-values are plotted against their physical chromosomal position. The broken red line represents the genome-wide level of significance (P < 5 × 10⁻⁸)