Table 1.
Non-diabetic | Diabetic | ||||
---|---|---|---|---|---|
Sham | IRI | Sham | IRI | ||
Blood glucose level (mg/dL) | 3w | 136.0 ± 4.7 | 131.5 ± 6.4 | 504.5 ± 42.4# | 568.7 ± 10.2# |
5w | 147.3 ± 4.1 | 157.0 ± 7.3 | 515.6 ± 49.8# | 442.4 ± 42.6# | |
Body weight (g) | 3w | 26.67 ± 1.17 | 25.08 ± 0.64 | 22.27 ± 0.87# | 20.62 ± 0.33# |
5w | 28.55 ± 0.86 | 28.30 ± 0.96† | 24.44 ± 0.81# | 22.20 ± 1.25# | |
Kidney weight (g) | 3w | 0.163 ± 0.008 | 0.107 ± 0.004* | 0.168 ± 0.005 | 0.097 ± 0.006* |
5w | 0.140 ± 0.007 | 0.105 ± 0.013 | 0.162 ± 0.008 | 0.062 ± 0.005*#† | |
Kidney to body weight ratio (%) | 3w | 0.613 ± 0.011 | 0.425 ± 0.014* | 0.756 ± 0.028# | 0.470 ± 0.029* |
5w | 0.490 ± 0.011† | 0.380 ± 0.060 | 0.669 ± 0.051# | 0.282 ± 0.026*† | |
Kidney length (cm) | 3w | 1.073 ± 0.021 | 0.901 ± 0.021* | 1.076 ± 0.010 | 0.844 ± 0.020* |
5w | 1.073 ± 0.015 | 0.902 ± 0.041* | 1.052 ± 0.011 | 0.743 ± 0.024*#† |
* p < 0.05 versus Sham, # p < 0.05 versus non-diabetic, † p < 0.05 versus values at 3 weeks.