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. 2017 Dec 1;7:16802. doi: 10.1038/s41598-017-17103-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Impact of a mitochondrial ROS scavenger on cardiac fibrosis and ROS levels and plasma leptin and aldosterone levels in control and obese rats. Heart from rats fed a standard diet (CT) or a high fat diet (HFD) treated with the mitochondrial ROS scavenger (MitoTempo; MT; 0.7 mg Kg⁻¹ day⁻¹) were analyzed. (a) Quantification of collagen volume fraction (CVF). (b) Representative microphotographs of myocardial sections staining with picrosirius red examined by light microscopy (magnification 40X). (c) Quantification of superoxide anions production and (d) representative microphotographs of myocardial sections labeled with DHE analyzed by fluorescence microscopy (magnification 40X). Plasma levels of leptin (e) and aldosterone (f) of the same animals. Bar graphs represent the mean ± SEM of 6–8 animals. Scale bar: 50 µm. *p < 0.05; **p < 0.01; ***p < 0.001 vs. control group. ^†p < 0.05; ^††p < 0.01; ^†††p < 0.001 vs. HFD group.