Table 1.
Effect of the mitochondrial reactive oxygen species scavenger (MitoTempo; MT; 0.7 mg Kg−1 day−1) on body weight, relative heart weight, echocardiographic parameters and systolic blood pressure in rats fed a standard diet (CT) or a high fat diet (HFD).
| CT | HFD | HFD + MT | |
|---|---|---|---|
| Body Weight (g). | 356.6 ± 10.7 | 442.8 ± 8.4*** | 397.8 ± 9.4 **†† |
| HW/TL (mg/cm tibia) | 24.7 ± 0.56 | 28.3 ± 1* | 25.9 ± 0.7 |
| IVT (mm) | 1.51 ± 0.12 | 1.38 ± 0.5 | 1.4 ± 0.06 |
| PWT(mm) | 1.46 ± 0.1 | 1.37 ± 0.06 | 1.45 ± 0.06 |
| EDD (mm) | 6.88 ± 0.43 | 7.21 ± 0.23 | 6.81 ± 0.11 |
| ESD (mm) | 3.40 ± 0.36 | 3.98 ± 0.27 | 3.75 ± 0.3 |
| EF (%) | 86.9 ± 2.8 | 79.6 ± 3.1 | 78.8 ± 3.6 |
| FS (%) | 48.5 ± 3.2 | 42.3 ± 3.3 | 44.4 ± 3.8 |
| E/A ratio | 1.96 ± 0.17 | 2.03 ± 0.17 | 1.91 ± 0.12 |
| SBP (mmHg) | 133.7 ± 2.5 | 138.1 ± 2.1 | 133.9 ± 2.6 |
HW: heart weight; TL: tibia length; IVT: interventricular septum thickness; PWT: posterior wall thickness; EDD: end-diastolic diameter; ESD: end-systolic diameter; EF: ejection fraction; FS: fractional shortening; E/A ratio; SBP: systolic blood pressure. Data values represent mean ± S.E.M of 8 animals. *p < 0.05; **p < 0.01; ***p < 0.001 vs. control group. ††p < 0.01 vs. HFD group.