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. 2017 Dec 1;7:16803. doi: 10.1038/s41598-017-16791-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic depicting the behavior of liposomes. Neutral liposomes localize at the surface mostly, and penetrate to a small extent, releasing ranibizumab which is then transported trans-sclerally. On the other hand, negatively charged liposomes penetrate intrasclerally and release the ranibizumab which then diffuses across the sclera. Positively charged liposomes, on the other hand remain localized episclerally and release the ranibizumab which diffuses across the sclera.