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. 2017 Dec 1;7:16696. doi: 10.1038/s41598-017-16959-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hydrogen-deuterium exchange mass spectrometry for cortactinCR. Percentage of deuterium uptake is indicated for HDX incubation periods ranging from 30 s to 240 min. Minimal changes in deuterium uptake are observed over the time course suggesting a minimal hydrophobic core for cortactinCR, and that the protein is largely unprotected and in an unfolded state. Alternating orange and black sequences indicate cortactin repeats.