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. 2017 Nov 27;20(1):32–43. doi: 10.1016/j.neo.2017.11.002

Figure 1.

Figure 1

Bo-786 cells generated osteolytic lesions in mouse femur. Bo-786 cells were injected into the femur of mouse right leg. (A) The growth of cancer cells in the right legs was monitored by BLI over 8 weeks. (B) Osteolytic bone lesions were detected by X-ray. (C) Micro-CT of the femurs with or without tumors. Quantification of BMD was done on whole femurs using Microview software. (D) A representative image of H&E-stained bone section of the leg shows the presence of tumor cells. A representative image of TRAP staining shows strong staining in PC3-mm2–injected femur but only weakly in Bo-786–injected femur. “L”: normal left femur; “R”: tumor cell injected right femur. **P < .01.