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. 2017 Nov 27;20(1):32–43. doi: 10.1016/j.neo.2017.11.002

Figure 6.

Figure 6

Knockdown of BIGH3 gene in Bo-786 cells reduced Bo-786-induced osteolytic lesions. (A) Representative micro-CT images of mouse femur 4 weeks after being injected with 786-shNS, 786-shBG#3, or 786-shBG#4 cells (upper). BMD of whole femur was quantified using Microview software (lower). (B) H&E-stained bone section of an injected femur showed the presence of tumor cells and IHC of BIGH3 on the adjacent sections of H&E. “shNS”: 786-shNS cells (nonsilencing control cells); “shBG#3”: 786-shBG#3 cells; “shBG#4”: 786-shBG#4 cells.