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Th17 and T-regulatory (Treg) share important developmental elements. After stimulation, naïve T cells can be induced into RORγt and Forkhead box P3 (Foxp3) double-positive T cells. Furthermore, whether naïve T cells differentiate to Th17 or Treg depends on the surrounding cytokines. In some situations, Th17 and Treg can trans-differentiate.
