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. 2017 Nov 27;10:396. doi: 10.3389/fnmol.2017.00396

Figure 3.

Figure 3

Constitutive activation of astrocytic Rac1 in the BLA impaired fear memory acquisition. (A) Representative images of BLA infected by AAV expressing mCherry, Rac1-DN or Rac1-CA. (B) Experimental design. A single CS-US paired conditioning trial. (C,D) Overexpression of Rac1-CA, but not Rac1-DN, in the BLA decreased freezing levels in cued memory test (mCherry: n = 12, Rac1-DN: n = 13, Rac1-CA: n = 11). (E) Experimental design. Five CS-US paired conditioning trials. (F,G) Overexpression of astrocytic Rac1-CA, but not Rac1-DN, in the BLA impaired fear memory acquisition (mCherry: n = 11–12, Rac1-CA: n = 12, Rac1 DN: n = 10). *p < 0.05, **p < 0.01, #p < 0.05. Scale bar, 100 μm.