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. 2017 Dec 2;10:44. doi: 10.1186/s13039-017-0343-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a Flowchart of the PicoBioChip manufacture: 1. standard cleaning, 2. photolithography, 3. Ag deposition, 4. etching, 5. Ag and photoresist removal, and 6.surface modification. b The porous morphology on the PicoBioChip with a “nano-on-nano” structure. c Conceptual illustration of how an PicoBioChip can be employed to achieve significantly enhanced capture of targeted cell