Table 3.
Multivariable analyses investigating the association between delta chloride (Δ Cl) from admission to 72 h post-admission and 1) any AKI at 72 h and 2) moderate/severe AKI at 72 h
| Variable | Any AKI Hyperchloremic Subgroup |
Moderate/Severe AKI Hyperchloremic Subgroup |
||
|---|---|---|---|---|
| Odds Ratio Multivariable |
P-value | Odds Ratio Multivariable |
P-value | |
|
ΔCl
per mEq/L increase |
1.04 (0.97–1.11) |
0.2652 | 1.03 (0.93–1.14) |
0.6164 |
| Male | 1.49 (0.60–3.70) |
0.3948 | 6.38 (1.16–34.99) |
0.0329 |
| Diabetes | 0.55 (0.20–1.50) |
0.2449 | 0.88 (0.21–3.73) |
0.8645 |
| Hypertension | 0.60 (0.26–1.36) |
0.2196 | 0.55 (0.15–1.95) |
0.3545 |
| Heart failure | 7.06 (1.33–37.52) |
0.0219 | 2.54 (0.15–43.62) |
0.5205 |
| Diuretic | 3.35 (1.26–8.91) |
0.0156 | 3.61 (0.74–17.60) |
0.1118 |
| Statin | 0.51 (0.20–1.30) |
0.1564 | 1.12 (0.26–4.83) |
0.8795 |
| Oliguria | 6.09 (1.66–22.39) |
0.0066 | 33.05 (4.89–223.45) |
0.0003 |
| CFB 72 h per 100 ml increase |
1.00 (1.00–1.01) |
0.4866 | 1.01 (1.00–1.02) |
0.1821 |
| Pressor or inotrope | 1.37 (0.51–3.69) |
0.5277 | 1.66 (0.35–8.01) |
0.5255 |
| Mechanical ventilation | 1.10 (0.36–3.32) |
0.8734 | 1.46 (0.26–8.37) |
0.6703 |
| Base Deficit per mEq/L increase |
1.05 (0.96–1.15) |
0.2777 | 1.12 (0.96–1.30) |
0.1411 |
| SOFA score per unit increase |
1.09 (0.95–1.25) |
0.2340 | 0.98 (0.80–1.20) |
0.8472 |
CFB = cumulative fluid balance; oliguria defined as urine output less than 500 ml in 24 h; anemia = admission hematocrit <39% for men and <36% for women;; SOFA = Sequential Organ Failure Assessment; Any AKI, KDIGO Stage ≥1 SCr-based; Moderate/severe AKI, KDIGO Stage ≥2 SCr-based
The two multivariate models are investigating the association between delta chloride at 72 h (ΔCl = Cl72 – Cl0) and 1) any AKI at 72 h and 2) moderate/severe AKI at 72 h in the hyperchloremic subgroup. Both models are adjusted for variables with P-value <0.25 on univariate analysis reported in Table 2