Table 1.
Timing of the invasive approach, definitive treatment, and clinical outcomes at follow-up for included RCTs comparing early and delayed strategies.
| Study, year (References) | Median time of catheterization, h | Patients, n | Definitive treatment (%) | Clinical outcomes at follow-up | |||
|---|---|---|---|---|---|---|---|
| Early strategy | Delayed strategy | Early strategy | Delayed strategy | Early strategy | Delayed strategy | ||
| ELISA, 2003 (van't Hof et al., 2003) | 6 | 50 | 109 | 111 | PCI:66 (60.5) CABG:15 (13.8) Medical:27 (24.7) |
PCI:64 (57.7) CABG:21 (18.9) Medical:26 (23.4) |
Death, MI, major bleeding, refractory ischemia at 1 month |
| ISAR-COOL, 2003 (Neumann et al., 2003) | 2.4 | 86 | 203 | 207 | PCI:143 (70.4) CABG:16 (7.9) Medical:44 (21.7) |
PCI:133 (64.3) CABG:16 (7.7) Medical:58 (28.0) |
Death, MI, major bleeding, refractory ischemia at 1 month |
| OPTIMA, 2009 (Riezebos et al., 2009) | 0.5 | 25 | 73 | 69 | PCI:73 (100) | PCI:69 (100) | Death, MI, major bleeding, re-PCI at 1 month |
| OPTIMA, 2016 (Oosterwerff et al., 2016) | Death, MI, re-PCI at 5 years | ||||||
| ABOARD, 2009 (Montalescot et al., 2009) | 1.1 | 20.5 | 175 | 177 | PCI:117 (66.9) CABG:16 (9.1) Medical:42 (24.0) |
PCI:105 (59.3) CABG:17 (9.6) Medical:55 (31.1) |
Death, MI, major bleeding, re-PCI, refractory ischemia at 1 month |
| TIMACS, 2009 (Mehta et al., 2009) | 14 | 50 | 1593 | 1438 | PCI:954 (59.9) CABG:255 (16.0) Medical:384 (24.1) |
PCI:796 (55.4) CABG:219 (15.2) Medical:423 (29.4) |
Death, MI, major bleeding, re-PCI, refractory ischemia at 6 months |
| Zhang et al., 2010 (Zhang et al., 2010) | 9.3 | 49.9 | 446 | 369 | PCI:314 (70.4) CABG:41 (9.2) Medical:91 (20.4) |
PCI:252 (68.3) CABG:37 (10.1) Medical:80 (21.6) |
Death, MI, major bleeding, re-PCI, refractory ischemia at 6 months |
| Sciahbasi, 2010 (Sciahbasi et al., 2010) | 5 | 24 | 27 | 27 | PCI:27 (100) | PCI:27 (100) | Death, re-PCI in 1 year |
| LIPSIA-NSTEMI, 2012 (Thiele et al., 2012) | 1.1 | 67.2 | 200 | 200 | PCI:151 (75.5) CABG:16 (8.0) Medical:33 (16.5) |
PCI:114 (57.0) CABG:25 (12.5) Medical:61 (30.5) |
Death, MI, refractory ischemia at 6 months, in-hospital major bleeding |
| ELISA3, 2013 (Badings et al., 2013) | 2.6 | 54.9 | 269 | 265 | PCI:180 (66.7) CABG:62 (23.2) Medical:27 (10.1) |
PCI:164 (61.9) CABG:68 (25.7) Medical:33 (12.4) |
Death, MI, major bleeding, refractory ischemia at 1 month |
| Tekin, 2013 (Tekin et al., 2013) | <24 | 24–72 | 69 | 62 | PCI:69 (100) | PCI:62 (100) | Death, MI, LVEF, re-hospitalization at 3 months |
| RIDDLE, 2015 (Milosevic et al., 2016) | 1.4 | 61 | 162 | 161 | PCI:127 (78.4) CABG:20 (12.3) Medical:15 (9.3) |
PCI:104 (65.0) CABG:38 (23.8) Medical:18 (11.2) |
Death, MI, major bleeding, refractory ischemia at 1 year |
| SISCA, 2015 (Reuter et al., 2015) | 2.8 | 20.9 | 83 | 87 | PCI:45 (58) CABG:8 (10) Medical:25 (32) |
PCI:45 (59) CABG:8 (11) Medical:23 (30) |
Death, MI, major bleeding, re-PCI at 1 month |
| Liu et al., 2015 (Liu et al., 2015) | <12 | 12–24 | 22 | 20 | PCI:22 (100) | PCI:20 (100) | Death, MI, major bleeding, re-PCI, refractory ischemia at 6 months |
ABOARD, Angioplasty to Blunt the Rise of Troponin in Acute Coronary Syndromes Randomized for an Immediate or Delayed Intervention; CABG, coronary artery bypass graft; ELISA, Early or Late Intervention in Unstable Angina; ISAR-COOL, Intracoronary Stenting with Antithrombotic Regimen Cooling Off; LIPSIA-NSTEMI, Leipzig Immediate vs. Early and Late Percutaneous Coronary Intervention Trial in Non–ST-Segment Elevation Myocardial Infarction; MI, myocardial infarction; PCI, percutaneous coronary intervention; RIDDLE, Randomized Study of Immediate vs. Delayed Invasive Intervention in Patients with Non-ST-segment Elevation Myocardial Infarction; SISCA, The Invasive Strategy in Acute Coronary Syndrome; TIMACS, Timing of Intervention in Acute Coronary Syndromes.