Table 2.
Clinical Characteristics of RCTs in Meta-analysis.
| Study, year (References) | Mean age, y | Female sex, n (%) | Diabetes, n (%) | ST-segment depression, n (%) | 3-vessel disease, n (%) | Glycoprotein IIb/IIIa inhibitors, n (%) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Early strategy | Delayed strategy | Early strategy | Early strategy | Early strategy | Delayed strategy | Early strategy | Delayed strategy | Early strategy | Delayed strategy | Early strategy | Delayed strategy | |
| ELISA, 2003 (van't Hof et al., 2003) | 63.0 | 65.0 | 79 (72.4) | 76 (68.4) | 16 (14.6) | 16 (14.4) | NA | NA | 31 (28.4) | 33 (29.7) | 0 (0.0) | 111 (100) |
| ISAR-COOL, 2003 (Neumann et al., 2003) | 70.0 | 70.0 | 67 (33.0) | 69 (33.3) | 53 (26.1) | 65 (31.4) | 133 (65.5) | 135 (65.2) | 94 (46.3) | 92 (44.4) | 203 (100) | 207 (100) |
| OPTIMA, 2009 (Riezebos et al., 2009)/2016 (Oosterwerff et al., 2016) | 63.0 | 62.0 | 22 (30.0) | 19 (26.0) | 14 (19.2) | 14 (20.3) | 38 (52.1) | 36 (52.2) | 10 (13.7) | 9 (13.0) | 71 (97.3) | 64 (92.8) |
| ABPARD, 2009 (Montalescot et al., 2009) | 65.0 | 65.0 | 48 (27.4) | 52 (29.4) | 38 (21.7) | 57 (32.2) | 122 (69.7) | 136 (76.8) | 32 (18.3) | 44 (24.9) | 114 (65.1) | 101 (57.1) |
| TIMACS, 2009 (Mehta et al., 2009) | 65.0 | 65.7 | 554 (34.8) | 498 (34.6) | 422 (26.5) | 394 (27.7) | 1282 (80.5) | 1149 (79.9) | 272 (171) | 227 (15.8) | 370 (23.2) | 322 (22.4) |
| Zhang et al., 2010 (Zhang et al., 2010) | 67.0 | 66.0 | 151 (33.9) | 119 (32.2) | 105 (23.5) | 83 (22.5) | 425 (95.3) | 349 (94.6) | 195 (43.7) | 148 (40.1) | 82 (18.4) | 79 (21.4) |
| Sciahbasi, 2010 (Sciahbasi et al., 2010) | 58.8 | 59.7 | 5 (18.5) | 3 (11.1) | 7 (26.0) | 5 (18.5) | NA | NA | 1 (4.0) | 2 (7.0) | 27 (100) | 27 (100) |
| LIPSIA, 2012 (Thiele et al., 2012) | 68.0 | 70.0 | 68 (34.0) | 72 (36.0) | 76 (38.0) | 64 (32.0) | 122 (61.0) | 124 (62.0) | 59 (39.5) | 63 (31.5) | 195 (97.5) | 197 (98.5) |
| ELISA3, 2013 (Badings et al., 2013) | 72.1 | 71.8 | 82 (30.5) | 91 (34.3) | 64 (23.8) | 54 (20.4) | NA | NA | 89 (33.0) | 70 (26.6) | NA | NA |
| Tekin, 2013 (Tekin et al., 2013) | 58.1 | 55.6 | 28 (40.6) | 18 (28.8) | 22 (31.9) | 28 (45.2) | 56 (81.2) | 50 (80.6) | 40 (58.1) | 35 (56.5) | NA | NA |
| RIDDLE, 2015 (Milosevic et al., 2016) | 60.5 | 63.0 | 48 (29.6) | 55 (34.2) | 35 (21.6) | 52 (32.3) | 125 (77.7) | 130 (80.7) | 57 (35.2) | 65 (40.6) | 152 (93.8) | 146 (90.7) |
| SISCA, 2015 (Reuter et al., 2015) | 63.9 | 66.5 | 25 (30.0) | 23 (27.0) | 35 (42.0) | 28 (33.0) | 63 (76.0) | 65 (76.0) | NA | NA | 83 (100) | 87 (100) |
| Liu et al., 2015 (Liu et al., 2015) | 80.4 | 80.3 | 11 (50.0) | 7 (35.0) | 11 (50.0) | 11 (55.0) | NA | NA | 7 (31.8) | 9 (45.0) | NA | NA |