Fig. 4.

siRNA-TERRA increased MMP in cells treated with H₂O₂. a Flow cytometry was used to analyze MMP: a. normal A549 cells, b. A549 cells treated with 120 μM of H₂O₂ alone for 12 h, c. A549 cells transfected with siRNA-negative control for 48 h and co-treated with 120 μM of H₂O₂ for 12 h, d. A549 cells transfected with siRNA-TERRA1 for 48 h and co-treated with 120 μM of H₂O₂ for 12 h, and e. A549 cells transfected with siRNA-TERRA2 for 48 h and co-treated with 120 μM of H₂O₂ for 12 h. b MMP results were quantitatively analyzed. Each bar represents mean ± SD, n = 6. ^** P < 0.01 compared with the normal control group. ^## P < 0.01 compared with the H₂O₂+ siRNA-TERRA negative control group