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. 2017 Dec 2;17:743. doi: 10.1186/s12879-017-2853-3

Table 3.

Specific gene mutations in resistant strains

Gene locus Band Gene region/mutation aRIF monoresistant bINH monoresistant cMDR
rpoB
WT1 506–509
WT2 510–513
WT3 513–517 d1
WT4 516–519
WT5 518–522
WT6 521–525
WT7 526–529 d3
WT8 530–533 1 1
MUT1 D516V 6
MUT2A H526Y d3
MUT2B H526D
MUT3 S531 L 1 1
katG
WT 315 d11 d4
MUT1 S315 T1 14 10
MUT2 S315 T2
inhA
WT1 −15/−16 d4 d1
WT2 −8 d1
MUT1 C15T d4 d1
MUT2 A16G
MUT3A T8C 6
MUT3B T8A

WT wild type band, MUT mutant band, RIF rifampicin, INH isoniazid, MDR multi-drug resistance

aIsolates with mutation(s) in the rpoB gene and none in the inhApro or katG gene

bIsolates with mutation(s) in the inhApro region and/or in the katG gene, with no mutation in the rpoB gene

cIsolates with mutations in the rpoB gene and inhApro and/or katG gene

dNumber of isolates that had presence of mutation band and the absence of corresponding wild type band