Table 3.
Gene locus | Band | Gene region/mutation | aRIF monoresistant | bINH monoresistant | cMDR |
---|---|---|---|---|---|
rpoB | |||||
WT1 | 506–509 | ||||
WT2 | 510–513 | ||||
WT3 | 513–517 | d1 | |||
WT4 | 516–519 | ||||
WT5 | 518–522 | ||||
WT6 | 521–525 | ||||
WT7 | 526–529 | d3 | |||
WT8 | 530–533 | 1 | 1 | ||
MUT1 | D516V | 6 | |||
MUT2A | H526Y | d3 | |||
MUT2B | H526D | ||||
MUT3 | S531 L | 1 | 1 | ||
katG | |||||
WT | 315 | d11 | d4 | ||
MUT1 | S315 T1 | 14 | 10 | ||
MUT2 | S315 T2 | ||||
inhA | |||||
WT1 | −15/−16 | d4 | d1 | ||
WT2 | −8 | d1 | |||
MUT1 | C15T | d4 | d1 | ||
MUT2 | A16G | ||||
MUT3A | T8C | 6 | |||
MUT3B | T8A |
WT wild type band, MUT mutant band, RIF rifampicin, INH isoniazid, MDR multi-drug resistance
aIsolates with mutation(s) in the rpoB gene and none in the inhApro or katG gene
bIsolates with mutation(s) in the inhApro region and/or in the katG gene, with no mutation in the rpoB gene
cIsolates with mutations in the rpoB gene and inhApro and/or katG gene
dNumber of isolates that had presence of mutation band and the absence of corresponding wild type band