Fig. 6.

PDE4B1-D564A transgenic mice show no clear differences in tests of anxiety-like behavior, antidepressant-like action, or learning/memory. Black bars: Wild-type (WT). Grey bars: PDE4B1-D564A (TG). Data are mean ± SE. a Elevated plus maze, time in each arm. b Elevated plus maze, explorations of closed and open arms. c Tail suspension test, time spent motionless. d Forced swim test, time spent motionless. e Prepulse inhibition, percent inhibition with progressive stimulus (percent inhibition at pre-pulses of 4, 8 and 16 dB, column pairs 1, 2, and 3). f Prepulse inhibition, amplitude of startle response. g Fear conditioning, baseline freezing. h Fear conditioning, contextual conditioning. i Fear conditioning, cued conditioning