Table 3.
Significance analysis of interaction effects in cytokine levels and clinical covariates
| Combined sex | Males | Females | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Effect | Chisq | Df | Pr(>Chisq) | Chisq | Df | Pr(>Chisq) | Chisq | Df | Pr(>Chisq) |
| (Intercept) | 387.78 | 1 | < 0.001 | 239.73 | 1 | < 0.001 | 105.51 | 1 | < 0.001 |
| Severity | 3.28 | 1 | 0.07 | 1.48 | 1 | 0.22 | 0.88 | 1 | 0.35 |
| Age | 0.01 | 1 | 0.91 | 0.12 | 1 | 0.73 | 0.44 | 1 | 0.51 |
| SRS | 0.13 | 1 | 0.72 | 0.06 | 1 | 0.81 | 1.35 | 1 | 0.25 |
| Sleep | 0.08 | 1 | 0.78 | 0.23 | 1 | 0.63 | 0.38 | 1 | 0.54 |
| GI | 0.53 | 1 | 0.47 | 0.96 | 1 | 0.33 | 0.25 | 1 | 0.62 |
| Analyte | 1079.27 | 26 | < 0.001 | 787.12 | 26 | < 0.001 | 247.60 | 26 | < 0.001 |
| Severity:analyte | 43.64 | 26 | 0.02 | 16.42 | 26 | 0.93 | 71.10 | 26 | < 0.001 |
| Age:analyte | 75.23 | 26 | < 0.001 | 60.36 | 26 | < 0.001 | 41.61 | 26 | 0.03 |
| SRS:analyte | 10.96 | 26 | 1.00 | 19.09 | 26 | 0.83 | 40.28 | 26 | 0.04 |
| Sleep:analyte | 17.09 | 26 | 0.91 | 12.47 | 26 | 0.99 | 28.20 | 26 | 0.35 |
| GI:analyte | 9.65 | 26 | 1.00 | 13.11 | 26 | 0.98 | 23.97 | 26 | 0.58 |
Analysis of deviance tables (type III Wald chi-square tests) for the statistical model: mY~(severity + age + sex + SRS + sleep + GI)*Analyte + (1|ID). Where mY represents the normalized log2 of the fluorescence responses with respect to run (Additional file 1: Figure S2)