Table 4.
Top ten canonical pathways affected by Vinyl Chloride exposure.
| Ingenuity canonical pathways | −log (p-value) |
Ratio | Molecules |
|---|---|---|---|
| tRNA charging | 2.01E01 | 2.35E-01 | AMP, L-phenylalanine, L-glutamine, L-asparagine, L-tryptophan, glycine, L-methionine, L-histidine, L-cysteine, L-valine, L-alanine, L-isoleucine, L-leucine, L-proline, L-threonine, L-aspartic acid, L-arginine, L-tyrosine, L-lysine |
| Superpathway of Citrulline Metabolism | 1.13E01 | 2.63E-01 | Citrulline, AMP, L-glutamine, L-proline, urea, phosphate, fumaric acid, L-aspartic acid,2-oxoglutaric acid, L-arginine |
| Urea Cycle | 9.05E00 | 3.5E-01 | Citrulline, AMP, urea, phosphate, fumaric acid, L-aspartic acid, L-arginine |
| Purine Nucleotides Degradation II (Aerobic) | 8.62E00 | 2.29E-01 | Xanthosine, AMP, inosine, uric acid, adenosine, phosphate, hypoxanthine, xanthine |
| Arginine Biosynthesis IV | 8.42E00 | 2.92E-01 | Citrulline, AMP, phosphate, fumaric acid, L-aspartic acid,2-oxoglutaric acid, L-arginine |
| Citrulline Biosynthesis | 8.15E00 | 2.69E-01 | citrulline,L-glutamine,L-proline,urea,phosphate,2-oxoglutaric acid, L-arginine |
| Adenosine Nucleotides Degradation II | 8.15E00 | 2.69E-01 | AMP, inosine, uric acid, adenosine, phosphate, hypoxanthine, xanthine |
| Purine Ribonucleosides Degradation to Ribose-1-phosphate | 7.68E00 | 3.33E-01 | Xanthosine, inosine, adenosine, phosphate, hypoxanthine, xanthine |
| Superpathway of Methionine Degradation | 7.66E00 | 1.41E-01 | Pyruvic acid,adenosine,betaine,phosphate,2-oxoglutaric acid, L-methionine, alpha-ketobutyric acid, dimethylglycine, L-cysteine |
| Phenylalanine Degradation IV (Mammalian, via Side Chain) | 7.46E00 | 2.05E-01 | AMP, l-phenylalanine, L-glutamine, alpha-N-phenylacetyl-L-glutamine, phenylpyruvic acid, glycine, 2-oxoglutaric acid, phenylacetic acid |