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. Author manuscript; available in PMC: 2018 Aug 15.
Published in final edited form as: Clin Cancer Res. 2017 Apr 19;23(16):4865–4874. doi: 10.1158/1078-0432.CCR-16-2987

Fig. 1. Comparison of global proteolytic activity in mucinous and nonmucinous cysts by MSP-MS.

Fig. 1

Volcano plots displaying the peptide cleavages generated by mucinous (n=16) and nonmucinous cysts (n=7) when assayed at pH 7.5 (A) or pH 3.5 (B). Spectral counts of peptide cleavage products were used for relative quantification of the fold change (mucinous/nonmucinous) and hypothesis testing. Cleavages that met the criteria for differentiating mucinous from nonmucinous cysts (+/− 1 log2(fold change), p < 0.05) are shown in blue. The substrate specificity of the cleavages within the red box is displayed with an iceLogo plot (C). Residues shown are statistically significant with p < 0.05.