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. Author manuscript; available in PMC: 2017 Dec 2.
Published in final edited form as: Clin Cancer Res. 2017 Sep 14;23(23):7312–7323. doi: 10.1158/1078-0432.CCR-16-2186

Figure 3.

Figure 3

Targeting of HA-terminated LbL nanoparticles to orthotopic lung cancer model using tumor cells derived from KP autochthonous mouse model. (a) Both healthy and tumored mice were treated with Cy-5.5 labelled LbL nanoparticles and whole-body fluorescence imaging were taken at 4 hrs, 24 hrs, & 48 hrs and tissues were harvested and imaged at 48 hrs. (b) Quantified recovered fluorescence intensities of different organs after harvest at 48 hours. The results represent mean ± Standard Deviation (S.D.) n = 4. (c) Tomato fluorescence of the KP tumor cells in harvested lungs and (d) CD44 immunohistochemistry staining confirmed tumor formation and tumor cell overexpression of CD44 in the lungs of the orthotopic model.