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. Author manuscript; available in PMC: 2018 Oct 23.
Published in final edited form as: Clin Exp Metastasis. 2017 Oct 23;34(6-7):401–410. doi: 10.1007/s10585-017-9864-8

Figure 4. Methods of transport across the BBB and potential drug delivery routes.

Figure 4

A–D) Common transport routes for solute molecules that are needed for normal brain metabolism. E–G) Transport routes that can be hijacked to deliver drugs to the brain. Drugs can be conjugated to insulin, transferrin, or albumin or loaded into liposomes, nanoparticles, or immune cells to utilize transcytosis pathways.

Reprinted by permission from Elsevier: Advanced Drug Delivery Reviews, copyright 2011.

Chen Y, Liu L. (2012) Modern methods for delivery of drugs across the blood-brain barrier. Advanced drug delivery reviews. 64: 640–65. PMID: 22154620