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. 2017 Sep 25;82(23):11961–11980. doi: 10.1021/acs.joc.7b02088

Figure 16.

Figure 16

–log Ki (μM) for FAAH versus Hammett σp, defining and quantitating a linear correlation between enzyme inhibition and the electronic impact of oxazole substituents on intrinsic reactivity of the electrophilic carbonyl of an α-ketoheterocycle (ρ = 3.0), some arising from single heavy atom substitution.