Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Active analogues required a single heavy atom exchange into the vinblastine structure (C20′ NH2 for OH). In a plot of –log IC50 (nM, HCT116) versus substituent σp, the analogues additionally displayed a predictable modulation of activity by a substituent (X) electronic effect, impacting benzamide carbonyl H-bonding with tubulin, some representing single heavy atom additions. All analogues shown are more active than vinblastine.
