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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Mol Cancer Res. 2017 Sep 18;15(12):1667–1677. doi: 10.1158/1541-7786.MCR-17-0333

Figure 5. In vivo effect of NIR-PIT for MOC2-luc tumor in a unilateral tumor model.

Figure 5

(A) NIR-PIT regimen. Bioluminescence and fluorescence images were obtained at each time point as indicated. (B) In vivo BLI of tumor bearing mice in response to NIR-PIT. Before NIR-PIT, tumors were approximately the same size and exhibited similar bioluminescence. The tumor treated by NIR-PIT showed decreasing luciferase activity after NIR-PIT. (C) Quantitative luciferase activity showed a significant decrease in NIR-PIT tumors (n ≧ 8, *p < 0.05 vs. other groups, **p < 0.01 vs. other groups, by Tukey’s t test with ANOVA). (D) In vivo IR700 fluorescence real-time imaging of tumor-bearing mice in response to NIR-PIT. The tumor treated by NIR-PIT showed decreasing IR700 fluorescence immediately after NIR-PIT. (E) Tumor growth was significantly inhibited in the NIR-PIT treatment groups (n ≧ 8, ***p < 0.001 vs. other groups, Tukey’s test with ANOVA). (F) Significantly prolonged survival was observed in the NIR-PIT treatment group (n ≧ 8, ***p < 0.001 vs. other groups, by Log-rank test).