Table 4.
Frequency of RCM features in DM, MIS, and non-desmoplastic invasive melanomas
| RCM Feature | No. (%)
|
||
|---|---|---|---|
| DM (n=16) | Non-DM in situ (n=27) | Non-DM invasive (n=27) | |
| Regular HC pattern | 11 (69) | 18 (67) | 13 (48) |
| Atypical HC | 10 (63) | 14 (52) | 16 (59) |
| Broadened HC | 6 (38) | 10 (37) | 13 (48) |
| Diamond-shaped HC | 0 | 0 | 0 |
| Cobblestone pattern | 3 (19) | 4 (15) | 1 (4) |
| Atypical cobblestone pattern | 0 | 3 (11) | 3 (11) |
| Atypical cobblestone pattern with small nucleated cells | 0 | 2 (7) | 2 (7) |
| Epidermal disarray | 6 (38) | 11 (41) | 5 (19) |
| HC atypical and disarray | 5 (31) | 5 (19) | 3 (11) |
| Pagetoid cells | 16 (100) | 27 (100) | 27 (100) |
| Widespread pagetoid infiltration | 10 (63) | 14 (52) | 12 (44) |
| Round pagetoid cells | 12 (75) | 22 (81) | 27 (100) |
| Dendritic pagetoid cells | 16 (100) | 25 (93) | 23 (85) |
| Pagetoid cells around follicular opening | 2 (13) | 6 (22) | 4 (15) |
| Edged papillae | 7 (44) | 13 (48) | 8 (30) |
| Non-edged papillae | 8 (50) | 19 (70) | 18 (67) |
| Large interpapillary space | 0 | 0 | 0 |
| Polycyclic papillae | 2 (13) | 7 (26) | 5 (19) |
| Papillae enlarged and polycyclic | 1 (6) | 3 (11) | 3 (11) |
| Non-visible papillae | 5 (31) | 7 (26) | 9 (33) |
| Cell atypia | 16 (100) | 27 (100) | 27 (100) |
| Marked atypia | 8 (50) | 14 (52) | 14 (52) |
| Sheet of cells | 4 (25) | 6 (22) | 6 (22) |
| Junctional nest | 4 (25) | 7 (26) | 6 (22) |
| Junctional clusters | 4 (25) | 6 (22) | 6 (22) |
| Junctional thickening | 1 (6) | 1 (4) | 2 (7) |
| Nests | 2 (13) | 6 (22) | 10 (37) |
| Dense nest | 0 | 3 (11) | 2 (7) |
| Dishomogenous nest | 2 (13) | 4 (15) | 9 (33) |
| Sparse nest | 1 (6) | 4 (15) | 6 (22) |
| Cerebriform nest | 0 | 0 | 3 (11) |
| Plump bright cells | 14 (88) | 16 (59) | 18 (67) |
| Plump bright cells in large aggregation within papillary dermis | 4 (25) | 5 (19) | 5 (19) |
| Vessels: visible | 5 (31) | 5 (19) | 8 (30) |
| Vertical vessel within the papillae | 1 (6) | 0 | 1 (4) |
| Horizontal vessel | 4 (25) | 5 (19) | 5 (19) |
| Linear telangiectasia-like horizontal vessel | 1 (6) | 2 (7) | 3 (11) |
| Convoluted glomerular-like vessel | 1 (6) | 1 (4) | 3 (11) |
| Hyporeflective pagetoid cells | 1 (6) | 4 (15) | 2 (7) |
| Spindle cells in superficial dermis | 8 (50) | 4 (15) | 7 (26) |
| Nucleated cells in dermis | 12 (75) | 9 (33) | 18 (67) |
| Dermal inflammation (mild) | 8 (50) | 4 (15) | 10 (37) |
| Dermal inflammation (florid) | 1 (6) | 0 | 3 (11) |
| Pagetoid spread (mild) | 4 (25) | 5 (19) | 11 (41) |
| Pagetoid spread (florid) | 11 (69) | 20 (74) | 15 (56) |
| Density of junctional melanocytes (mild) | 7 (44) | 11 (41) | 15 (56) |
| Density of junctional melanocytes (florid) | 7 (44) | 12 (44) | 7 (26) |
RCM, reflectance confocal microscopy; DM, desmoplastic melanoma; HC, honeycomb.